Using antibodies to control DNA-templated chemical reactions
نویسندگان
چکیده
منابع مشابه
Dna-templated Chemical Reactions:
INTRODUCTION Nature has produced the most selective and efficient catalysts known, often in the form of enzymes having well defined structures to direct substrate recognition and subsequent catalysis of chemical transformations. These capabilities have inspired multiple research efforts focused on the development of supramolecular assemblies that mimic enzymes by serving as templates for chemic...
متن کاملNucleic Acid Templated Reactions for Chemical Biology
Nucleic acid directed bioorthogonal reactions offer the fascinating opportunity to unveil and redirect a plethora of intracellular mechanisms. Nano- to picomolar amounts of specific RNA molecules serve as templates and catalyze the selective formation of molecules that 1) exert biological effects, or 2) provide measurable signals for RNA detection. Turnover of reactants on the template is a val...
متن کاملCatalytic antibodies: the rerouting of chemical reactions.
The research outlined above resulted from a collaborative effort with Professor K. Brocklehurst at Queen Mary and Westfield College, University of London. I thank Professor Brocklehurst, Dr. Caroline S. Jackson, Dr. Mark Searcey, and other members of our research groups involved in the above investigations. I also thank Therapeutic Antibodies Inc. and the Wellcome Trust for financial support. I090
متن کاملDirecting otherwise incompatible reactions in a single solution by using DNA-templated organic synthesis.
General methods for translating amplifiable information carriers such as DNA into synthetic molecules may enable the evolution of non-natural molecules through iterated cycles of translation, selection, and amplification that are currently available only to proteins and nucleic acids. During the process of developing such a method, we recently discovered that DNA templates can sequence-specific...
متن کاملSwitchable supramolecular catalysis using DNA-templated scaffolds.
Switchable β-cyclodextrin (β-CD)-induced hydrolysis of m-tert-butylphenyl acetate is demonstrated in the presence of supramolecular β-CD/adamantane oligonucleotide scaffolds. In one system, a duplex between a β-CD-functionalized nucleic acid and an adamantane-nucleic acid leads to a switchable catalytic system. In a second system, a β-CD/adamantane duplex is cooperatively generated by K(+)-stab...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2020
ISSN: 2041-1723
DOI: 10.1038/s41467-020-20024-3